Combined RNAi-Mediated Suppression of Rictor and EGFR Resulted in Complete Tumor Regression in an Orthotopic Glioblastoma Tumor Model

The PI3K/AKT/mTOR pathway is commonly over activated in glioblastoma (GBM), and Rictor was shown to be an important regulator downstream of this pathway. EGFR overexpression is also frequently found in GBM tumors, and both EGFR and Rictor are associated with increased proliferation, invasion, metast...

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Bibliografiske detaljer
Main Authors: Verreault, Maite, Weppler, Sherry A., Stegeman, Amelia, Warburton, Corinna, Strutt, Dita, Masin, Dana, Bally, Marcel B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598699/
https://ncbi.nlm.nih.gov/pubmed/23555046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059597
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