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Regulation of Argonaute Slicer Activity by Guide RNA 3′ End Interactions with the N-terminal Lobe
Structural studies indicate that binding of both the guide RNA (siRNA and miRNA) and the target mRNA trigger substantial conformational changes in the Argonaute proteins. Here we explore the role of the N-terminal lobe (and its PAZ domain) in these conformational changes using biochemical and cell c...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597821/ https://ncbi.nlm.nih.gov/pubmed/23329841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441030 |
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