Regulation of Argonaute Slicer Activity by Guide RNA 3′ End Interactions with the N-terminal Lobe

Structural studies indicate that binding of both the guide RNA (siRNA and miRNA) and the target mRNA trigger substantial conformational changes in the Argonaute proteins. Here we explore the role of the N-terminal lobe (and its PAZ domain) in these conformational changes using biochemical and cell c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hur, Junho K., Zinchenko, Michelle K., Djuranovic, Sergej, Green, Rachel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
RNA
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597821/
https://ncbi.nlm.nih.gov/pubmed/23329841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441030
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