Lewis acid catalysis of phosphoryl transfer from a copper(II)-NTP complex in a kinase ribozyme

The chemical strategies used by ribozymes to enhance reaction rates are revealed in part from their metal ion and pH requirements. We find that kinase ribozyme K28(1-77)C, in contrast with previously characterized kinase ribozymes, requires Cu(2+) for optimal catalysis of thiophosphoryl transfer fro...

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Bibliographic Details
Main Authors: Biondi, Elisa, Poudyal, Raghav R., Forgy, Joshua C., Sawyer, Andrew W., Maxwell, Adam W. R., Burke, Donald H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597699/
https://ncbi.nlm.nih.gov/pubmed/23358821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt039
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