Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA

Nucleophosmin (NPM1) is an abundant nucleolar protein implicated in ribosome maturation and export, centrosome duplication and response to stress stimuli. NPM1 is the most frequently mutated gene in acute myeloid leukemia. Mutations at the C-terminal domain led to variant proteins that aberrantly an...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Chiarella, Sara, De Cola, Antonella, Scaglione, Giovanni Luca, Carletti, Erminia, Graziano, Vincenzo, Barcaroli, Daniela, Lo Sterzo, Carlo, Di Matteo, Adele, Di Ilio, Carmine, Falini, Brunangelo, Arcovito, Alessandro, De Laurenzi, Vincenzo, Federici, Luca
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Molecular Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597674/
https://ncbi.nlm.nih.gov/pubmed/23328624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt001
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items