Comparative Cardiac Toxicity of Anthracyclines In Vitro and In Vivo in the Mouse

PURPOSE: The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well as in the mouse in vivo. METHODS: The ca...

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Main Authors: Toldo, Stefano, Goehe, Rachel W., Lotrionte, Marzia, Mezzaroma, Eleonora, Sumner, Evan T., Biondi-Zoccai, Giuseppe G. L., Seropian, Ignacio M., Van Tassell, Benjamin W., Loperfido, Francesco, Palazzoni, Giovanni, Voelkel, Norbert F., Abbate, Antonio, Gewirtz, David A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597611/
https://ncbi.nlm.nih.gov/pubmed/23516478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058421
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