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Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.

GTPase-activating protein (GAP) is a cytosolic protein that stimulates the rate of hydrolysis of GTP (GTP to GDP) bound to normal p21ras, but does not catalyze the hydrolysis of GTP bound to oncogenic, activated forms of the ras protein. Transformation of cells with v-src or activated transforming v...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Bouton, A H, Kanner, S B, Vines, R R, Wang, H C, Gibbs, J B, Parsons, J T
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1991
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359756/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1703633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.2.945-953.1991
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