The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

Optimal immune activation of naïve CD8 T cells requires signal 1 mediated by the T cell receptor, signal 2 mediated by co-stimulation and signal 3 provided by pro-inflammatory cytokines. However, the potential for signal 3 cytokines to rescue anti-viral responses in functionally exhausted T cells ha...

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Bibliographic Details
Main Authors: Schurich, Anna, Pallett, Laura J., Lubowiecki, Marcin, Singh, Harsimran D., Gill, Upkar S., Kennedy, Patrick T., Nastouli, Eleni, Tanwar, Sudeep, Rosenberg, William, Maini, Mala K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597507/
https://ncbi.nlm.nih.gov/pubmed/23516358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003208
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