In-vivo measurement of LDOPA uptake, dopamine reserve and turnover in the rat brain using [(18)F]FDOPA PET

Longitudinal measurements of dopamine (DA) uptake and turnover in transgenic rodents may be critical when developing disease-modifying therapies for Parkinson's disease (PD). We demonstrate methodology for such measurements using [(18)F]fluoro-3,4-dihydroxyphenyl-L-alanine ([(18)F]FDOPA) positr...

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Main Authors: Walker, Matthew D, Dinelle, Katherine, Kornelsen, Rick, McCormick, Siobhan, Mah, Chenoa, Holden, James E, Farrer, Matthew J, Stoessl, A Jon, Sossi, Vesna
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597374/
https://ncbi.nlm.nih.gov/pubmed/22929441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.120
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