Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin–dependent signaling

Neutrophil entry into the lung tissues is a key step in host defense to bacterial and yeast infections, but if uncontrolled can lead to severe tissue damage. Here, we demonstrate for the first time that sialic acid binding Ig-like lectin E (siglec-E) functions to selectively regulate early neutrophi...

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Detalhes bibliográficos
Main Authors: McMillan, Sarah J., Sharma, Ritu S., McKenzie, Emma J., Richards, Hannah E., Zhang, Jiquan, Prescott, Alan, Crocker, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596968/
https://ncbi.nlm.nih.gov/pubmed/23315163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449983
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