Repair of deletions and double-strand gaps by homologous recombination in a mammalian in vitro system.
We have designed an in vitro system using mammalian nuclear extracts, or fractions derived from them, that can restore the sequences missing at double-strand breaks (gaps) or in deletions. The recombination substrates consist of (i) recipient DNA, pSV2neo with gaps or deletions ranging from 70 to 39...
Guardat en:
| Publicat a: | Mol Cell Biol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359648/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1986239/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.1.445-457.1991 |
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