Knockdown of Pyruvate Carboxylase or Fatty Acid Synthase Lowers Numerous Lipids and Glucose-Stimulated Insulin Release in Insulinoma Cells

We previously showed that knockdown of the anaplerotic enzyme pyruvate carboxylase in the INS-1 832/13 insulinoma cell line inhibited glucose-stimulated insulin release and glucose carbon incorporation into lipids. We now show that knockdown of fatty acid synthase (FAS) mRNA and protein also inhibit...

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Hlavní autoři: MacDonald, Michael J., Hasan, Noaman M., Dobrzyn, Agnieszka, Stoker, Scott W., Ntambi, James M., Liu, Xueqing, Sampath, Harini
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596477/
https://ncbi.nlm.nih.gov/pubmed/23357280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2013.01.002
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