Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk

BACKGROUND: Global DNA hypomethylation is an early molecular event in carcinogenesis. Whether methylation measured in peripheral blood mononuclear cells(PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established. METHODS: From an original sample-...

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Hauptverfasser: Friso, Simonetta, Udali, Silvia, Guarini, Patrizia, Pellegrini, Camilla, Pattini, Patrizia, Moruzzi, Sara, Girelli, Domenico, Pizzolo, Francesca, Martinelli, Nicola, Corrocher, Roberto, Olivieri, Oliviero, Choi, Sang-Woon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596466/
https://ncbi.nlm.nih.gov/pubmed/23300023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-12-0859
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