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Structure of the Atg12–Atg5 conjugate reveals a platform for stimulating Atg8–PE conjugation
Atg12 is conjugated to Atg5 through enzymatic reactions similar to ubiquitination. The Atg12–Atg5 conjugate functions as an E3-like enzyme to promote lipidation of Atg8, whereas lipidated Atg8 has essential roles in both autophagosome formation and selective cargo recognition during autophagy. Howev...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596133/ https://ncbi.nlm.nih.gov/pubmed/23238393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.208 |
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