Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition with no cure. Mitochondrial dysfunction, Ca(2+) overloading and local hypoxic/ischemic environments have been implicated in the pathophysiology of ALS and are conditions that may initiate metabolic acidosis in the affected tissue....

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Bibliografiske detaljer
Main Authors: Behan, Á T, Breen, B, Hogg, M, Woods, I, Coughlan, K, Mitchem, M, Prehn, J H M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595486/
https://ncbi.nlm.nih.gov/pubmed/23306556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.158
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