Postinduction Dexamethasone and Individualized Dosing of Escherichia Coli L-Asparaginase Each Improve Outcome of Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia: Results From a Randomized Study—Dana-Farber Cancer Institute ALL Consortium Protocol 00-01

PURPOSE: We assessed the toxicity and efficacy of dexamethasone and a novel dosing method of Escherichia coli L-asparaginase (EC-Asnase) in children and adolescents with newly diagnosed acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Patients achieving complete remission (CR) on Dana-Farbe...

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Auteurs principaux: Vrooman, Lynda M., Stevenson, Kristen E., Supko, Jeffrey G., O'Brien, Jane, Dahlberg, Suzanne E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Kelly, Kara M., Kutok, Jeffery L., Laverdière, Caroline, Lipshultz, Steven E., Michon, Bruno, Schorin, Marshall, Relling, Mary V., Cohen, Harvey J., Neuberg, Donna S., Sallan, Stephen E., Silverman, Lewis B.
Format: Artigo
Langue:Inglês
Publié: American Society of Clinical Oncology 2013
Sujets:
ORIGINAL REPORTS
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595424/
https://ncbi.nlm.nih.gov/pubmed/23358966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.43.2070
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