Postinduction Dexamethasone and Individualized Dosing of Escherichia Coli L-Asparaginase Each Improve Outcome of Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia: Results From a Randomized Study—Dana-Farber Cancer Institute ALL Consortium Protocol 00-01

PURPOSE: We assessed the toxicity and efficacy of dexamethasone and a novel dosing method of Escherichia coli L-asparaginase (EC-Asnase) in children and adolescents with newly diagnosed acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Patients achieving complete remission (CR) on Dana-Farbe...

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Autori principali: Vrooman, Lynda M., Stevenson, Kristen E., Supko, Jeffrey G., O'Brien, Jane, Dahlberg, Suzanne E., Asselin, Barbara L., Athale, Uma H., Clavell, Luis A., Kelly, Kara M., Kutok, Jeffery L., Laverdière, Caroline, Lipshultz, Steven E., Michon, Bruno, Schorin, Marshall, Relling, Mary V., Cohen, Harvey J., Neuberg, Donna S., Sallan, Stephen E., Silverman, Lewis B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2013
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595424/
https://ncbi.nlm.nih.gov/pubmed/23358966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.43.2070
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