A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

Agents that interfere with mitotic progression by disturbing microtubule dynamics are commonly used for cancer treatment. Previously, a series of aroylquinolone regioisomers as novel microtubule inhibitors were discovered. One of these new compounds, MPT0B214 inhibited tubulin polymerization through...

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Autores principales: Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Ping, Kuo, Ching-Chuan, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595215/
https://ncbi.nlm.nih.gov/pubmed/23554962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058953
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