Role of Substratum Stiffness in Modulating Genes Associated with Extracellular Matrix and Mechanotransducers YAP and TAZ

PURPOSE. Primary open-angle glaucoma is characterized by increased resistance to aqueous humor outflow and a stiffer human trabecular meshwork (HTM). Two Yorkie homologues, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif, encoded by WWTR1 (TAZ), are mechanotransdu...

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Autores principales: Raghunathan, Vijay Krishna, Morgan, Joshua T., Dreier, Britta, Reilly, Christopher M., Thomasy, Sara M., Wood, Joshua A., Ly, Irene, Tuyen, Binh C., Hughbanks, Marissa, Murphy, Christopher J., Russell, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594895/
https://ncbi.nlm.nih.gov/pubmed/23258147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-11007
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