Control of NOD2 and Rip2 dependent innate immune activation by GEF-H1

BACKGROUND: Genetic variants of nucleotide-binding oligomerization domain 2 (NOD2) lead to aberrant microbial recognition and can cause chronic inflammatory diseases in patients with Crohn’s disease. METHODS: We utilized gene specific siRNA mediated knockdown and expression of GEF-H1 in wildtype, Ri...

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Bibliografiske detaljer
Main Authors: Zhao, Yun, Cotoner, Carmen Alonso, Ballester, Isabel, Song, Joo Hye, Chang, Sun Young, Guleng, Bayasi, Arihiro, Seiji, Murray, Peter J., Xavier, Ramnik, Kobayashi, Koichi S., Reinecker, Hans-Christian
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594873/
https://ncbi.nlm.nih.gov/pubmed/21887730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21851
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