RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway choice by regulating 5′ end resection, but how this is achieved remains uncertain. Here we report that Rif1(−/−) mice are seve...

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Autors principals: Chapman, J. Ross, Barral, Patricia, Vannier, Jean-Baptiste, Borel, Valérie, Steger, Martin, Tomas-Loba, Antonia, Sartori, Alessandro A., Adams, Ian R., Batista, Facundo D., Boulton, Simon J.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594748/
https://ncbi.nlm.nih.gov/pubmed/23333305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.01.002
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