The inhibitor of volume-regulated anion channels DCPIB activates TREK potassium channels in cultured astrocytes

BACKGROUND AND PURPOSE: The ethacrynic acid derivative, 4-(2-butyl-6,7-dichlor-2-cyclopentylindan-1-on-5-yl) oxobutyric acid (DCPIB) is considered to be a specific and potent inhibitor of volume-regulated anion channels (VRACs). In the CNS, DCPIB was shown to be neuroprotective through mechanisms pr...

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Hlavní autoři: Minieri, L, Pivonkova, H, Caprini, M, Harantova, L, Anderova, M, Ferroni, S
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594680/
https://ncbi.nlm.nih.gov/pubmed/23072356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12011
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