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Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases fH-dependent resistance of peripheral platelets to complement attack
Crry and DAF are two murine membrane C3 complement regulators with overlapping functions. Crry deletion is embryonically lethal while DAF-deficient mice are generally healthy. Crry(−/−)DAF(−/−) mice were viable on a C3(−/−) background, but platelets from such mice were rapidly destroyed when transfu...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594628/ https://ncbi.nlm.nih.gov/pubmed/23390291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202536 |
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