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Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases fH-dependent resistance of peripheral platelets to complement attack

Crry and DAF are two murine membrane C3 complement regulators with overlapping functions. Crry deletion is embryonically lethal while DAF-deficient mice are generally healthy. Crry(−/−)DAF(−/−) mice were viable on a C3(−/−) background, but platelets from such mice were rapidly destroyed when transfu...

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Detalhes bibliográficos
Main Authors: Barata, Lidia, Miwa, Takashi, Sato, Sayaka, Kim, David, Mohammed, Imran, Song, Wen-Chao
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594628/
https://ncbi.nlm.nih.gov/pubmed/23390291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202536
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