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Familial melanoma-associated mutations in p16 uncouple its tumor suppressor functions
Familial melanoma is associated with point mutations in the cyclin-dependent kinase (CDK) inhibitor p16(INK4A) (p16). We recently reported that p16 regulates intracellular oxidative stress in a cell cycle-independent manner. Here, we constructed 12 different familial melanoma-associated point mutant...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594444/ https://ncbi.nlm.nih.gov/pubmed/23190892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.401 |
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