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Epidermal Growth Factor Regulates Hematopoietic Regeneration Following Radiation Injury

The mechanisms which regulate HSC regeneration following myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow (BM) serum of mice bearing deletion of Bak and Bax in Tie2(+) cells (Tie2Cre;Bak1(−/−);Bax(fl/−) mice), which...

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Detalhes bibliográficos
Main Authors: Doan, Phuong L., Himburg, Heather A., Helms, Katherine, Russell, J. Lauren, Fixsen, Emma, Quarmyne, Mamle, Harris, Jeffrey R., Deoliviera, Divino, Sullivan, Julie M., Chao, Nelson J., Kirsch, David G., Chute, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594347/
https://ncbi.nlm.nih.gov/pubmed/23377280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3070
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