Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures

Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(−) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABA(A) receptors in the perinatal period. The most com...

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Hauptverfasser: Cleary, Ryan T., Sun, Hongyu, Huynh, Thanhthao, Manning, Simon M., Li, Yijun, Rotenberg, Alexander, Talos, Delia M., Kahle, Kristopher T., Jackson, Michele, Rakhade, Sanjay N., Berry, Gerard, Jensen, Frances E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594228/
https://ncbi.nlm.nih.gov/pubmed/23536761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057148
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