Steviol Reduces MDCK Cyst Formation and Growth by Inhibiting CFTR Channel Activity and Promoting Proteasome-Mediated CFTR Degradation

Cyst enlargement in polycystic kidney disease (PKD) involves cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This study aimed to investigate an inhibi...

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Bibliografiske detaljer
Main Authors: Yuajit, Chaowalit, Homvisasevongsa, Sureeporn, Chatsudthipong, Lisa, Soodvilai, Sunhapas, Muanprasat, Chatchai, Chatsudthipong, Varanuj
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594167/
https://ncbi.nlm.nih.gov/pubmed/23536832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058871
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