Antidiarrheal efficacy of a quinazolin CFTR inhibitor on human intestinal epithelial cell and in mouse model of cholera

OBJECTIVE: This study aimed to evaluate the antidiarrheal efficacy and pharmacological properties of ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate (DQA) as an inhibitor of cystic fibrosis transmembrane conductance regulator protein (CFTR) both in vitro and in vivo. MATERIALS AND ME...

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Main Authors: Patanayindee, Jenvit, Muanprasat, Chatchai, Soodvilai, Sunhapas, Chatsudthipong, Varanuj
格式: Artigo
語言:Inglês
出版: Medknow Publications & Media Pvt Ltd 2012
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480796/
https://ncbi.nlm.nih.gov/pubmed/23112425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0253-7613.100392
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