An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions

Emerging evidence suggests that inflammation provides a link between obesity and insulin resistance. The noncanonical IκB kinases IKKε and TANK-binding kinase 1 (TBK1) are induced in liver and fat after high fat diet by NF-κB activation, and in turn initiate a program of counter-inflammation that pr...

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Autors principals: Reilly, Shannon M., Chiang, Shian-Huey, Decker, Stuart J., Chang, Louise, Uhm, Maeran, Larsen, Martha J., Rubin, John R., Mowers, Jonathan, White, Nicole M., Hochberg, Irit, Downes, Michael, Yu, Ruth, Liddle, Christopher, Evans, Ronald M., Oh, Dayoung, Li, Pingping, Olefsky, Jerrold M., Saltiel, Alan R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594079/
https://ncbi.nlm.nih.gov/pubmed/23396211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3082
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