Minimizing the Inhibitory Effect of Neutralizing Antibody for Efficient Gene Expression in the Liver With Adeno-associated Virus 8 Vectors

Neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) are known to interfere with AAV vector-mediated gene transfer by intravascular delivery. Evading the inhibitory effects of antibodies against AAV vectors is necessary for efficient transfer of therapeutic genes clinically. For th...

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Autors principals: Mimuro, Jun, Mizukami, Hiroaki, Hishikawa, Shuji, Ikemoto, Tomokazu, Ishiwata, Akira, Sakata, Asuka, Ohmori, Tsukasa, Madoiwa, Seiji, Ono, Fumiko, Ozawa, Keiya, Sakata, Yoichi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594013/
https://ncbi.nlm.nih.gov/pubmed/23247100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.258
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