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mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
In cycling cells, transcription of ribosomal RNA genes by RNA polymerase I (Pol I) is tightly coordinated with cell growth. Here, we show that the mammalian target of rapamycin (mTOR) regulates Pol I transcription by modulating the activity of TIF-IA, a regulatory factor that senses nutrient and gro...
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| Publicado en: | Genes Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359396/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15004009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.285504 |
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