mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

In cycling cells, transcription of ribosomal RNA genes by RNA polymerase I (Pol I) is tightly coordinated with cell growth. Here, we show that the mammalian target of rapamycin (mTOR) regulates Pol I transcription by modulating the activity of TIF-IA, a regulatory factor that senses nutrient and gro...

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Vydáno v:Genes Dev
Hlavní autoři: Mayer, Christine, Zhao, Jian, Yuan, Xuejun, Grummt, Ingrid
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359396/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15004009/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.285504
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