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Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
The subnuclear location and chromatin state of the immunoglobulin heavy-chain (IgH) locus have been implicated in the control of V(D)J recombination. V(H)-to-DJ(H) rearrangement of distal, but not proximal V(H) genes, furthermore, depends on the B-lineage commitment factor Pax5 (BSAP). Here we demon...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC359395/ https://ncbi.nlm.nih.gov/pubmed/15004008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.291504 |
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