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Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression
The mechanisms by which β-amyloid (Aβ), a peptide fragment believed to contribute to Alzheimer’s disease, leads to synaptic deficits are not known. Here we find that elevated oligomeric Aβ requires ion flux-independent function of NMDA receptors (NMDARs) to produce synaptic depression. Aβ activates...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593880/ https://ncbi.nlm.nih.gov/pubmed/23431156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219605110 |
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