Crystal structure of microsomal prostaglandin E(2) synthase provides insight into diversity in the MAPEG superfamily

Prostaglandin E(2) (PGE(2)) is a key mediator in inflammatory response. The main source of inducible PGE(2), microsomal PGE(2) synthase-1 (mPGES-1), has emerged as an interesting drug target for treatment of pain. To support inhibitor design, we have determined the crystal structure of human mPGES-1...

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Detaylı Bibliyografya
Asıl Yazarlar: Sjögren, Tove, Nord, Johan, Ek, Margareta, Johansson, Patrik, Liu, Gang, Geschwindner, Stefan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593876/
https://ncbi.nlm.nih.gov/pubmed/23431194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218504110
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