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Crystal structure of microsomal prostaglandin E(2) synthase provides insight into diversity in the MAPEG superfamily
Prostaglandin E(2) (PGE(2)) is a key mediator in inflammatory response. The main source of inducible PGE(2), microsomal PGE(2) synthase-1 (mPGES-1), has emerged as an interesting drug target for treatment of pain. To support inhibitor design, we have determined the crystal structure of human mPGES-1...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593876/ https://ncbi.nlm.nih.gov/pubmed/23431194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218504110 |
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