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Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L. Not...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593849/ https://ncbi.nlm.nih.gov/pubmed/23412334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301045110 |
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