Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L. Not...

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Bibliographic Details
Main Authors: Wang, Eric, Kawaoka, Shinpei, Yu, Ming, Shi, Junwei, Ni, Ting, Yang, Wenjing, Zhu, Jun, Roeder, Robert G., Vakoc, Christopher R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593849/
https://ncbi.nlm.nih.gov/pubmed/23412334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301045110
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