Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens

Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in which the connective polypeptide 1 (CP1) amino acid editing domain that clears mischarged tRNAs are missing (Mycoplasma mobile) or highly degenerate (Mycoplasma synoviae). Thus, these enzymes rely on a clearance pathway called pretr...

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Главные авторы: Li, Li, Palencia, Andrés, Lukk, Tiit, Li, Zhi, Luthey-Schulten, Zaida A., Cusack, Stephen, Martinis, Susan A., Boniecki, Michal T.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593832/
https://ncbi.nlm.nih.gov/pubmed/23431144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218374110
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