HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients

BACKGROUND: In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor receptor (EGFR)-targeted therapies. To identify additional predictive markers, we investigated the importance of HER2, the primary EGFR dimer...

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Hlavní autoři: Martin, V, Landi, L, Molinari, F, Fountzilas, G, Geva, R, Riva, A, Saletti, P, De Dosso, S, Spitale, A, Tejpar, S, Kalogeras, K T, Mazzucchelli, L, Frattini, M, Cappuzzo, F
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593567/
https://ncbi.nlm.nih.gov/pubmed/23348520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.4
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