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Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras.

Previously we found that negatively charged residues at positions 62, 63, and 69 of H-Ras are involved in binding to the CDC25 guanine nucleotide exchange factor (GEF). Using site-directed mutagenesis, we have changed conserved, positively charged residues of CDC25GEF to glutamic acid. We find the n...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Park, W, Mosteller, R D, Broek, D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359350/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7969149/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.12.8117
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