CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.

T cells that lack the CD45 transmembrane tyrosine phosphatase have a variety of T-cell receptor (TCR) signaling defects that are corrected by reexpression of wild-type CD45 or its intracytoplasmic domains. In this study, a chimeric molecule containing the myristylation sequence of Src and the intrac...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Niklinska, B B, Hou, D, June, C, Weissman, A M, Ashwell, J D
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359346/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7526153/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.12.8078
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