cRGD Peptide-Conjugated Icosahedral closo-B(12) (2−) Core Carrying Multiple Gd(3+)-DOTA Chelates for α(v)β(3) Integrin-Targeted Tumor Imaging (MRI)

A vertex-differentiated icosahedral closo-B(12)(2−) core was utilized to construct a α(v)β(3) integrin receptor-targeted (via cRGD peptide) high payload MRI contrast agent (CA-12) carrying 11 copies of Gd(3+)-DOTA chelates attached to the closo-B(12)(2−) surface via suitable linkers. The resulting p...

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Hlavní autoři: Goswami, Lalit N., Ma, Lixin, Cai, Quanyu, Sarma, Saurav J., Jalisatgi, Satish S., Hawthorne, M. Frederick
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593306/
https://ncbi.nlm.nih.gov/pubmed/23391150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic302340c
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