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Secondary mechanisms of diversification in the human antibody repertoire

V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges. V(D)J recombination efficiently generate a virtually limitless dive...

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Autors principals: Briney, Bryan S., Jr., James E. Crowe
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593266/
https://ncbi.nlm.nih.gov/pubmed/23483107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00042
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