Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is an inherited disorder of phagocytes in which NADPH oxidase is defective in generating reactive oxygen species. In this study, we reprogrammed three normal unrelated patient's fibroblasts (p47(phox) and gp91(phox)) to pluripotency by lentiviral transduction...

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Autores principales: Jiang, Yan, Cowley, Sally A, Siler, Ulrich, Melguizo, Dario, Tilgner, Katarzyna, Browne, Cathy, Dewilton, Angus, Przyborski, Stefan, Saretzki, Gabriele, James, William S, Seger, Reinhard A, Reichenbach, Janine, Lako, Majlinda, Armstrong, Lyle
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593166/
https://ncbi.nlm.nih.gov/pubmed/22311747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1053
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