Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is an inherited disorder of phagocytes in which NADPH oxidase is defective in generating reactive oxygen species. In this study, we reprogrammed three normal unrelated patient's fibroblasts (p47(phox) and gp91(phox)) to pluripotency by lentiviral transduction...

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Detalhes bibliográficos
Main Authors: Jiang, Yan, Cowley, Sally A, Siler, Ulrich, Melguizo, Dario, Tilgner, Katarzyna, Browne, Cathy, Dewilton, Angus, Przyborski, Stefan, Saretzki, Gabriele, James, William S, Seger, Reinhard A, Reichenbach, Janine, Lako, Majlinda, Armstrong, Lyle
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593166/
https://ncbi.nlm.nih.gov/pubmed/22311747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1053
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