Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; TGFB1; APOA4; APOC3; SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. In a case–control stud...

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Main Authors: Soerensen, Mette, Dato, Serena, Tan, Qihua, Thinggaard, Mikael, Kleindorp, Rabea, Beekman, Marian, Suchiman, H. Eka D., Jacobsen, Rune, McGue, Matt, Stevnsner, Tinna, Bohr, Vilhelm A., de Craen, Anton J. M., Westendorp, Rudi G. J., Schreiber, Stefan, Slagboom, P. Eline, Nebel, Almut, Vaupel, James W., Christensen, Kaare, Christiansen, Lene
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592963/
https://ncbi.nlm.nih.gov/pubmed/22234866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9373-7
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