The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs)

It is well known that attenuated insulin/insulin-like growth factor signaling (IIS) has a positive effect on longevity in several animal species, including mice. Here, we demonstrate that a population of murine pluripotent very small embryonic-like stem cells (VSELs) that reside in bone marrow (BM)...

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Main Authors: Kucia, Magda, Masternak, Michal, Liu, Riu, Shin, Dong-Myung, Ratajczak, Janina, Mierzejewska, Katarzyna, Spong, Adam, Kopchick, John J., Bartke, Andrzej, Ratajczak, Mariusz Z.
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592960/
https://ncbi.nlm.nih.gov/pubmed/22218782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9364-8
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