A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?

Tissue and organ rejuvenation and senescence/aging are closely related to the function of stem cells. Recently, we demonstrated that a population of pluripotent Oct-4(+) SSEA-1(+)Sca-1(+)Lin(-)CD45(-) very small embryonic-like stem cells (VSELs) resides in the adult murine bone marrow (BM) and other...

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Autors principals: Ratajczak, Mariusz Z., Shin, Dong-Myung, Ratajczak, Janina, Kucia, Magda, Bartke, Andrzej
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2010
Matèries:
Research Perspective
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006029/
https://ncbi.nlm.nih.gov/pubmed/21084728
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