Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells

We analyzed the activity of the histone deacetylase inhibitor (HDACi) suberoyl-anilide hydroxamic acid (SAHA) on Kasumi-1 acute myeloid leukemia (AML) cells expressing AML1/ETO. We also compared the effects of SAHA to those of valproic acid (VPA), a short-chain fatty acid HDACi. SAHA and VPA induced...

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Библиографические подробности
Главные авторы: Barbetti, Valentina, Gozzini, Antonella, Cheloni, Giulia, Marzi, Ilaria, Fabiani, Emiliano, Santini, Valeria, Dello Sbarba, Persio, Rovida, Elisabetta
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2013
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592907/
https://ncbi.nlm.nih.gov/pubmed/23321683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.23538
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