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Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice
CD73 functions as an ecto-5′-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models. Survival of wild-type (WT) recipients of either allogeneic donor naïve...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3592842/ https://ncbi.nlm.nih.gov/pubmed/23520507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058397 |
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