Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice

CD73 functions as an ecto-5′-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models. Survival of wild-type (WT) recipients of either allogeneic donor naïve...

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Bibliographic Details
Main Authors: Wang, Long, Fan, Jie, Chen, Siqi, Zhang, Yi, Curiel, Tyler J., Zhang, Bin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592842/
https://ncbi.nlm.nih.gov/pubmed/23520507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058397
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