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Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

We have investigated the functional role of the SH2 domain of the 85-kDa subunit (p85) of the phosphatidylinositol 3-kinase in the insulin signal transduction pathway. Microinjection of a bacterial fusion protein containing the N-terminal SH2 domain of p85 inhibited insulin- and other growth factor-...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Jhun, B H, Rose, D W, Seely, B L, Rameh, L, Cantley, L, Saltiel, A R, Olefsky, J M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 1994
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359282/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7935461/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.11.7466
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