Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10

Altered inflammatory cytokine profiles are often observed in individuals suffering from major depression. Recent clinical work reports on elevated IL-6 and decreased IL-10 in depression. Elevated IL-6 has served as a consistent biomarker of depression and IL-10 is proposed to influence depressive be...

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Detalhes bibliográficos
Main Authors: Voorhees, Jeffrey L., Tarr, Andrew J., Wohleb, Eric S., Godbout, Jonathan P., Mo, Xiaokui, Sheridan, John F., Eubank, Timothy D., Marsh, Clay B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592793/
https://ncbi.nlm.nih.gov/pubmed/23520517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058488
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